gamma- and mu-Heavy chain diseases and related disorders.
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چکیده
منابع مشابه
y - and P - Heavy chain diseases and related disorders 1 EDWARD
During the last ten years studies of myeloma proteins have shown them to be similar to or identical with normal immunoglobulins. In addition, the not infrequent occurrence of structural variants of immunoglobulins in association with neoplasms of lymphocytes or plasma cells has become widely recognized. Since the discovery of the group of heavy chain diseases in man (Franklin, Meltzer, Guggenhe...
متن کاملTubulointerstitial nephritis accompanying gamma-heavy chain deposition and gamma-heavy chain restricted plasma cells in the kidney.
Monoclonal immunoglobulin heavy chain (HC) diseases are rare proliferative disorders of B lymphocytes or plasma cells characterized by the presence of monoclonal α-, µ-, or γ-HC without associated light chains in the blood, urine, or both. We report a 59-year-old woman with a history of Hodgkin disease who developed hypercalcemia, proteinuria, and impaired kidney function. Protein electrophores...
متن کاملHuman immunoglobulin heavy-chain minilocus recombination in transgenic mice: gene-segment use in mu and gamma transcripts.
We (N.L. and L.D.T.) have introduced a human heavy-chain minilocus into mice transgenically. Constructs contain 2 heavy-chain variable (VH; psi VH3-105 and VH5-251), 10 diversity (D), 6 heavy-chain joining (JH), and either constant (C)mu or C mu and C gamma gene segments. Several founder lines were established and studied before immunization. Seventy heavy-chain transcripts were cloned and sequ...
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A patient, CAL, with gamma heavy chain disease is presented who has had a complete remission lasting over 2 yr with combination chemotherapy consisting of pulsatile cyclophosphamide and prednisone. The patient exhibited many features of an autoimmune process including a vasculitis, low serum complement levels, a positive antiglobulin (Coombs) test, Raynaud’s phenomenon, and keratoconjunctivitis...
متن کاملExcessive amounts of mu heavy chain block B-cell development.
Antigen-independent B-cell development occurs in several stages that depend on the expression of Ig heavy and light chain. We identified a line of mice that lacked mature B cells in the spleen. This mouse line carried approximately 11 copies of a transgene of the murine heavy chain constant region locus, and B-lineage cells expressed excessive amounts of the intracellular μ heavy chain. B-cell ...
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ژورنال
عنوان ژورنال: Journal of Clinical Pathology
سال: 1975
ISSN: 0021-9746
DOI: 10.1136/jcp.s1-6.1.65